The Crystal Structure of DJ-1, a Protein Related to Parkinson's Disease
نویسندگان
چکیده
منابع مشابه
The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.
Mutations in DJ-1, a human gene with homologues in organisms from all kingdoms of life, have been shown to be associated with autosomal recessive, early onset Parkinson's disease (PARK7). We report here the three-dimensional structure of the DJ-1 protein, determined at a resolution of 1.1 A by x-ray crystallography. The chain fold of DJ-1 resembles those of a bacterial protein, PfpI, that has b...
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15 صفحه اولExpression of the Parkinson's disease-related protein DJ-1 during neural stem cell proliferation.
Neural stem cells (NSCs) arise through neurogenesis, and comprise all newly-formed neurons in the central and peripheral nervous systems. DJ-1 is associated with autosomal recessive familial Parkinson's disease (PD). The relationship between DJ-1 and NSC proliferation may shed light on the underlying pathogenesis of, and potential treatments for, PD. To investigate the relationship between DJ-1...
متن کاملMitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.
Both homozygous (L166P, M26I, deletion) and heterozygous mutations (D149A, A104T) in the DJ-1 gene have been identified in Parkinson's disease (PD) patients. The biochemical function and subcellular localization of DJ-1 protein have not been clarified. To date the localization of DJ-1 protein has largely been described in studies over-expressing tagged DJ-1 protein in vitro. It is not known whe...
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ژورنال
عنوان ژورنال: Nihon Kessho Gakkaishi
سال: 2005
ISSN: 0369-4585,1884-5576
DOI: 10.5940/jcrsj.47.390